Gene Knowledge Graph UTC
Sensitive

Celiac disease

PTPN2 · rs11875687

Where this position leads

Condition: Celiac Disease

rs11875687 Condition: Celiac Disease Celiac Disease Condition rs11875687 rs11875687 PTPN2

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Celiac disease compared to the general population. (GWAS Catalog, Nat Genet 2011, PMID:22057235)
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Celiac disease. (GWAS Catalog, Nat Genet 2011, PMID:22057235)
T/T Published research associates this genotype with typical/baseline likelihood of Celiac disease — no copies of the reported risk allele. (GWAS Catalog, Nat Genet 2011, PMID:22057235)
Source
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease
Trynka G, Hunt KA, Bockett NA, Romanos J, Mistry V, Szperl A, Bakker SF, Bardella MT, Bhaw-Rosun L, Castillejo G, de la Concha EG, de Almeida RC
and 52 more — show all
Dias KR, van Diemen CC, Dubois PC, Duerr RH, Edkins S, Franke L, Fransen K, Gutierrez J, Heap GA, Hrdlickova B, Hunt S, Plaza Izurieta L, Izzo V, Joosten LA, Langford C, Mazzilli MC, Mein CA, Midah V, Mitrovic M, Mora B, Morelli M, Nutland S, Núñez C, Onengut-Gumuscu S, Pearce K, Platteel M, Polanco I, Potter S, Ribes-Koninckx C, Ricaño-Ponce I, Rich SS, Rybak A, Santiago JL, Senapati S, Sood A, Szajewska H, Troncone R, Varadé J, Wallace C, Wolters VM, Zhernakova A, Thelma BK, Cukrowska B, Urcelay E, Bilbao JR, Mearin ML, Barisani D, Barrett JC, Plagnol V, Deloukas P, Wijmenga C, van Heel DA
Spanish Consortium on the Genetics of Coeliac Disease (CEGEC) · PreventCD Study Group · Wellcome Trust Case Control Consortium (WTCCC)
Nature genetics · 2011 · PMID 22057235 · open access

Questions about rs11875687

What is rs11875687?

rs11875687 is a single position in the genome, in or near the PTPN2 gene. Published research associates it with celiac disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11875687 linked to?

On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs11875687 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11875687 come from?

GWAS Catalog, Nat Genet 2011, PMID:22057235. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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