Standard

Hip shape mode 3

near CASC17 · rs11868415

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻⁹, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 38,175 European ancestry individuals, 5,310 East Asian ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.04 higher (95% confidence interval 0.02-0.06); p = 5 × 10⁻¹⁰.

How common The A allele had a frequency of about 33% in the people studied.

Where it sits Chromosome 17, band 17q24.3 — between genes, 83.6 kb from CASC17.

What each result means

A/A Two copies of the version the research linked to Hip shape mode 3. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/C One copy of the version the research linked to Hip shape mode 3. That is a smaller link than two copies.

C/C No copy of the version the research linked to Hip shape mode 3. This is the starting point the study compared everyone against.

Source

The genetic architecture of hip shape and its role in the development of hip osteoarthritis and fracture

Faber BG, Frysz M, Zheng J, Lin H, Flynn KA, Ebsim R, Saunders FR, Beynon R, Gregory JS, Aspden RM, Harvey NC, Lindner C

and 7 more — show all

Cootes T, Evans DM, Davey Smith G, Gao X, Wang S, Kemp JP, Tobias JH

Human molecular genetics · 2025 · PMID 39574169 · open access

Questions about rs11868415

What is rs11868415?

rs11868415 is a single position in the genome, in or near the near CASC17 gene. Published research associates it with hip shape mode 3. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs11868415 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11868415 come from?

GWAS Catalog, Human molecular genetics 2025, PMID:39574169. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Hip shape mode 3 (rs11868415). MyGeneLog™. https://www.mygenelog.com/variants/rs11868415

← See all variants