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Who was studied 354,862 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0299 lower (95% confidence interval 0.02-0.04); p = 3 × 10−9.
How common The A allele had a frequency of about 95% in the people studied.
Where it sits Chromosome 15, band 15q21.1 — in an intron of SEMA6D.
What each result means
A/ATwo copies of the version the research linked to Depressive symptoms (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Depressive symptoms (MTAG). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Depressive symptoms (MTAG). This is the starting point the study compared everyone against.
Nature genetics · 2018 · PMID 29292387 · open access
Questions about rs11855468
What is rs11855468?
rs11855468 is a single position in the genome, in or near the SEMA6D gene. Published research associates it with depressive symptoms (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11855468 linked to?
On MyGeneLog this position is linked to Depression (Self-Reported Symptoms). The research behind each link, and its sources, are set out on that condition page.
Does having rs11855468 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11855468 come from?
GWAS Catalog, Nat Genet 2018, PMID:29292387. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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