Standard

QRS duration

SIPA1L1 · rs11848785

Where this position leads

Condition: Cardiac Conduction Intervals (PR Interval and QRS Duration)

What the study found

Who was studied up to 77,898 European ancestry individuals, up to 7,695 African American individuals; replicated in up to 111,874 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.437 ms lower (95% confidence interval 0.36-0.51); p = 1 × 10⁻³⁰.

How common The G allele had a frequency of about 24% in the people studied.

Where it sits Chromosome 14, band 14q24.2 — in an intron of SIPA1L1.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of QRS duration — no copies of the reported risk allele.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with QRS duration.

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of QRS duration compared to the general population.

Source

Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6

Prins BP, Mead TJ, Brody JA, Sveinbjornsson G, Ntalla I, Bihlmeyer NA, van den Berg M, Bork-Jensen J, Cappellani S, Van Duijvenboden S, Klena NT, Gabriel GC

and 101 more — show all

Liu X, Gulec C, Grarup N, Haessler J, Hall LM, Iorio A, Isaacs A, Li-Gao R, Lin H, Liu CT, Lyytikäinen LP, Marten J, Mei H, Müller-Nurasyid M, Orini M, Padmanabhan S, Radmanesh F, Ramirez J, Robino A, Schwartz M, van Setten J, Smith AV, Verweij N, Warren HR, Weiss S, Alonso A, Arnar DO, Bots ML, de Boer RA, Dominiczak AF, Eijgelsheim M, Ellinor PT, Guo X, Felix SB, Harris TB, Hayward C, Heckbert SR, Huang PL, Jukema JW, Kähönen M, Kors JA, Lambiase PD, Launer LJ, Li M, Linneberg A, Nelson CP, Pedersen O, Perez M, Peters A, Polasek O, Psaty BM, Raitakari OT, Rice KM, Rotter JI, Sinner MF, Soliman EZ, Spector TD, Strauch K, Thorsteinsdottir U, Tinker A, Trompet S, Uitterlinden A, Vaartjes I, van der Meer P, Völker U, Völzke H, Waldenberger M, Wilson JG, Xie Z, Asselbergs FW, Dörr M, van Duijn CM, Gasparini P, Gudbjartsson DF, Gudnason V, Hansen T, Kääb S, Kanters JK, Kooperberg C, Lehtimäki T, Lin HJ, Lubitz SA, Mook-Kanamori DO, Conti FJ, Newton-Cheh CH, Rosand J, Rudan I, Samani NJ, Sinagra G, Smith BH, Holm H, Stricker BH, Ulivi S, Sotoodehnia N, Apte SS, van der Harst P, Stefansson K, Munroe PB, Arking DE, Lo CW, Jamshidi Y

Genome biology · 2018 · PMID 30012220 · open access

Questions about rs11848785

What is rs11848785?

rs11848785 is a single position in the genome, in or near the SIPA1L1 gene. Published research associates it with qrs duration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11848785 linked to?

On MyGeneLog this position is linked to Cardiac Conduction Intervals (PR Interval and QRS Duration). The research behind each link, and its sources, are set out on that condition page.

Does having rs11848785 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11848785 come from?

GWAS Catalog, Genome biology 2018, PMID:30012220. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

QRS duration (rs11848785). MyGeneLog™. https://www.mygenelog.com/variants/rs11848785

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