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Osteoarthritis

MCF2L · rs11842874

Where this position leads

Condition: Knee Osteoarthritis

rs11842874 Condition: Knee Osteoarthritis Knee Osteoarthritis Condition rs11842874 rs11842874 MCF2L

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Osteoarthritis compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Osteoarthritis.
G/G Published research associates this genotype with typical/baseline likelihood of Osteoarthritis — no copies of the reported risk allele.
Source
A variant in MCF2L is associated with osteoarthritis
Day-Williams AG, Southam L, Panoutsopoulou K, Rayner NW, Esko T, Estrada K, Helgadottir HT, Hofman A, Ingvarsson T, Jonsson H, Keis A, Kerkhof HJ
and 33 more — show all
Thorleifsson G, Arden NK, Carr A, Chapman K, Deloukas P, Loughlin J, McCaskie A, Ollier WE, Ralston SH, Spector TD, Wallis GA, Wilkinson JM, Aslam N, Birell F, Carluke I, Joseph J, Rai A, Reed M, Walker K, Doherty SA, Jonsdottir I, Maciewicz RA, Muir KR, Metspalu A, Rivadeneira F, Stefansson K, Styrkarsdottir U, Uitterlinden AG, van Meurs JB, Zhang W, Valdes AM, Doherty M, Zeggini E
arcOGEN Consortium
American journal of human genetics · 2011 · PMID 21871595

Questions about rs11842874

What is rs11842874?

rs11842874 is a single position in the genome, in or near the MCF2L gene. Published research associates it with osteoarthritis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11842874 linked to?

On MyGeneLog this position is linked to Knee Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs11842874 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11842874 come from?

GWAS Catalog, Am J Hum Genet 2011, PMID:21871595. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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