Sensitive

Endometrial cancer

KLF12 · rs11841589

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻¹⁰, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 2,082 European ancestry endometrioid cases, 130 European ancestry cases, 9,544 European ancestry controls; replicated in 4,553 European ancestry endometrioid cases, 972 European ancestry cases, 27,600 European ancestry controls.

The effect Each copy of the G allele carried 1.15 times the odds of Endometrial cancer (95% confidence interval 1.11-1.21); p = 5 × 10⁻¹¹.

How common The G allele had a frequency of about 74% in the people studied.

Where it sits Chromosome 13, band 13q22.1 — between genes, 13.5 kb from RNY1P8.

How common each version is

GT

Korean KRGDB

G 96.5% · T 3.5%

Korean Korea4K

G 96.8% · T 3.2%

Korean Korea1K

G 96.5% · T 3.5%

Japanese ToMMo

G 81.5% · T 18.4%

Vietnamese

G 99.1% · T 0.9%

World gnomAD

G 69.5% · T 30.5%

World 1000 Genomes

G 72.5% · T 27.5%

World TOPMed

G 68.2% · T 31.8%

By ancestry gnomAD

East Asian

G 95.1% · T 4.9%

European (non-Finnish)

G 72.3% · T 27.7%

African / African American

G 56.9% · T 43.1%

South Asian

G 69.7% · T 30.3%

Admixed American (Latino)

G 74.6% · T 25.4%

Middle Eastern

G 64.0% · T 36.0%

Finnish

G 82.0% · T 18.0%

Ashkenazi Jewish

G 67.3% · T 32.7%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study. The ancestry rows are gnomAD's own groups (via Ensembl), as the survey defines them, not races.

What each result means

G/G Two copies of the version the research linked to Endometrial cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.

G/T One copy of the version the research linked to Endometrial cancer. That is a smaller link than two copies.

T/T No copy of the version the research linked to Endometrial cancer. This is the starting point the study compared everyone against.

Source

Five endometrial cancer risk loci identified through genome-wide association analysis

Cheng TH, Thompson DJ, O'Mara TA, Painter JN, Glubb DM, Flach S, Lewis A, French JD, Freeman-Mills L, Church D, Gorman M, Martin L

and 76 more — show all

National Study of Endometrial Cancer Genetics Group (NSECG) · Australian National Endometrial Cancer Study Group (ANECS) · RENDOCAS · AOCS Group

Nature genetics · 2016 · PMID 27135401 · open access

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Endometrial cancer (rs11841589). MyGeneLog™. https://www.mygenelog.com/variants/rs11841589

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