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Subjective well-being

SIK3 · rs11827828

What the study found

Who was studied 563,176 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.016 lower (95% confidence interval 0.01-0.022); p = 1 × 10−9.

How common The A allele had a frequency of about 15% in the people studied.

Where it sits Chromosome 11, band 11q23.3 — in an intron of SIK3.

What each result means

A/A Two copies of the version the research linked to Subjective well-being. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Subjective well-being. That is a smaller link than two copies.
G/G No copy of the version the research linked to Subjective well-being. This is the starting point the study compared everyone against.
Source

Questions about rs11827828

What is rs11827828?

rs11827828 is a single position in the genome, in or near the SIK3 gene. Published research associates it with subjective well-being. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs11827828 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11827828 come from?

GWAS Catalog, Nature human behaviour 2022, PMID:35589828. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Subjective well-being (rs11827828). MyGeneLog™. https://www.mygenelog.com/variants/rs11827828

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