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White blood cell count

GNA12 · rs1182182

Where this position leads

Condition: Blood Cell Counts

rs1182182 Condition: Blood Cell Counts Blood Cell Counts Condition rs1182182 rs1182182 GNA12

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−19, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 746,667 African American or Afro-Caribbean, African ancestry, European ancestry, East Asian ancestry, Hispanic or Latin American and South Asian ancestry individuals.

The effect The reported allele is T; the catalogue records no effect size ; p = 7 × 10−20.

How common The T allele had a frequency of about 28% in the people studied.

Where it sits Chromosome 7, band 7p22.2 — in an intron of GNA12.

What each result means

C/C No copy of the version the research linked to White blood cell count. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to White blood cell count. That is a smaller link than two copies.
T/T Two copies of the version the research linked to White blood cell count. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs1182182

What is rs1182182?

rs1182182 is a single position in the genome, in or near the GNA12 gene. Published research associates it with white blood cell count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1182182 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs1182182 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1182182 come from?

GWAS Catalog, Cell 2020, PMID:32888493. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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White blood cell count (rs1182182). MyGeneLog™. https://www.mygenelog.com/variants/rs1182182

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