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Cholesterol, total

CETP · rs118146573

Where this position leads

Condition: Cholesterol (LDL, HDL and Total)

Drug: Statins

rs118146573 Condition: Cholesterol (LDL, HDL and Total) Cholesterol (LDL, HDL and Total) Condition Drug: Statins Statins Drug rs118146573 rs118146573 CETP

What the study found

Who was studied 3,701 Mexican ancestry individuals; replicated in 5,114 Mexican ancestry individuals, 903 Mexican ancestry individuals from 73 dyslipidemic families.

The effect Each copy of the A allele shifted the measure 0.2 lower; p = 4 × 10−10.

Where it sits Chromosome 16, band 16q13 — in an intron of CETP.

What each result means

A/A Two copies of the version the research linked to Cholesterol, total. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Cholesterol, total. That is a smaller link than two copies.
G/G No copy of the version the research linked to Cholesterol, total. This is the starting point the study compared everyone against.
Source

Questions about rs118146573

What is rs118146573?

rs118146573 is a single position in the genome, in or near the CETP gene. Published research associates it with cholesterol, total. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs118146573 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

Does rs118146573 affect how medicines work?

CETP carries pharmacogenomic findings for Statins. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs118146573 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs118146573 come from?

GWAS Catalog, Nat Commun 2014, PMID:24886709. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Cholesterol, total (rs118146573). MyGeneLog™. https://www.mygenelog.com/variants/rs118146573

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