Standard
Sphingomyelin (d18:1/14:0) levels/Sphingomyelin (d16:1/16:0) levels
SGPP1 · rs118120036
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 4,492 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.415 higher (95% confidence interval 0.28-0.55); p = 5 × 10−9.
Where it sits Chromosome 14, band 14q23.2 — in an intron of SGPP1.
What each result means
A/A
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Sphingomyelin (d18:1/14:0) levels/Sphingomyelin (d16:1/16:0) levels compared to the general population.
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Sphingomyelin (d18:1/14:0) levels/Sphingomyelin (d16:1/16:0) levels.
G/G
Published research associates this genotype with typical/baseline likelihood of Sphingomyelin (d18:1/14:0) levels/Sphingomyelin (d16:1/16:0) levels — no copies of the reported risk allele.
Source
Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease
Cadby G,
Giles C,
Melton PE,
Huynh K,
Mellett NA,
Duong T,
Nguyen A,
Cinel M,
Smith A,
Olshansky G,
Wang T,
Brozynska M
and 32 more — show all
Inouye M,
McCarthy NS,
Ariff A,
Hung J,
Hui J,
Beilby J,
Dubé MP,
Watts GF,
Shah S,
Wray NR,
Lim WLF,
Chatterjee P,
Martins I,
Laws SM,
Porter T,
Vacher M,
Bush AI,
Rowe CC,
Villemagne VL,
Ames D,
Masters CL,
Taddei K,
Arnold M,
Kastenmüller G,
Nho K,
Saykin AJ,
Han X,
Kaddurah-Daouk R,
Martins RN,
Blangero J,
Meikle PJ,
Moses EK
Nature communications · 2022 · PMID 35668104 · open access
Questions about rs118120036
What is rs118120036?
rs118120036 is a single position in the genome, in or near the SGPP1 gene. Published research associates it with sphingomyelin (d18:1/14:0) levels/sphingomyelin (d16:1/16:0) levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs118120036 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs118120036 come from?
GWAS Catalog, Nature communications 2022, PMID:35668104. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Sphingomyelin (d18:1/14:0) levels/Sphingomyelin (d16:1/16:0) levels (rs118120036). MyGeneLog™. https://www.mygenelog.com/variants/rs118120036
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