Standard

Aspartate aminotransferase to alanine aminotransferase ratio

KIFC2 · rs117970388

Where this position leads

Condition: Gout

rs117970388 Condition: Gout Gout Condition rs117970388 rs117970388 KIFC2

What the study found

Who was studied 341,165 European ancestry individuals, 5,981 African ancestry individuals, 7,309 South Asian ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0405 lower (95% confidence interval 0.028-0.053); p = 5 × 10−10.

Where it sits Chromosome 8, band 8q24.3 — a synonymous change in KIFC2.

What each result means

A/A Two copies of the version the research linked to Aspartate aminotransferase to alanine aminotransferase ratio. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Aspartate aminotransferase to alanine aminotransferase ratio. That is a smaller link than two copies.
G/G No copy of the version the research linked to Aspartate aminotransferase to alanine aminotransferase ratio. This is the starting point the study compared everyone against.
Source

Questions about rs117970388

What is rs117970388?

rs117970388 is a single position in the genome, in or near the KIFC2 gene. Published research associates it with aspartate aminotransferase to alanine aminotransferase ratio. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs117970388 linked to?

On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.

Does having rs117970388 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs117970388 come from?

GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Aspartate aminotransferase to alanine aminotransferase ratio (rs117970388). MyGeneLog™. https://www.mygenelog.com/variants/rs117970388

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