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Psoriasis

DDX58 · rs11795343

Where this position leads

Condition: Psoriasis

rs11795343 Condition: Psoriasis Psoriasis Condition rs11795343 rs11795343 DDX58

What the study found

Who was studied 4,212 European ancestry cases, 8,032 European ancestry controls.

The effect Each copy of the T allele carried 1.19 times the odds of Psoriasis (95% confidence interval 1.155-1.226); p = 6 × 10−9.

Where it sits Chromosome 9, band 9p21.1 — in an intron of RIGI.

What each result means

C/C No copy of the version the research linked to Psoriasis. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Psoriasis. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Psoriasis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms
Baurecht H, Hotze M, Brand S, Büning C, Cormican P, Corvin A, Ellinghaus D, Ellinghaus E, Esparza-Gordillo J, Fölster-Holst R, Franke A, Gieger C
and 26 more — show all
Hubner N, Illig T, Irvine AD, Kabesch M, Lee YA, Lieb W, Marenholz I, McLean WH, Morris DW, Mrowietz U, Nair R, Nöthen MM, Novak N, O'Regan GM, Schreiber S, Smith C, Strauch K, Stuart PE, Trembath R, Tsoi LC, Weichenthal M, Barker J, Elder JT, Weidinger S, Cordell HJ, Brown SJ
Psoriasis Association Genetics Extension
American journal of human genetics · 2015 · PMID 25574825 · open access

Questions about rs11795343

What is rs11795343?

rs11795343 is a single position in the genome, in or near the DDX58 gene. Published research associates it with psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11795343 linked to?

On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.

Does having rs11795343 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11795343 come from?

GWAS Catalog, Am J Hum Genet 2015, PMID:25574825. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Psoriasis (rs11795343). MyGeneLog™. https://www.mygenelog.com/variants/rs11795343

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