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Non-supine apnea hypopnea index

ANK1 · rs117949693

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻⁸, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 6,246 Han Chinese ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.325 lower (95% confidence interval 0.22-0.43); p = 4 × 10⁻⁹.

How common The G allele had a frequency of about 3% in the people studied.

Where it sits Chromosome 8, band 8p11.21 — in an intron of ANK1.

What each result means

A/A No copy of the version the research linked to Non-supine apnea hypopnea index. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Non-supine apnea hypopnea index. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Non-supine apnea hypopnea index. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-Wide Association Study of Obstructive Sleep Apnea and Objective Sleep-related Traits Identifies Novel Risk Loci in Han Chinese Individuals

Xu H, Liu F, Li Z, Li X, Liu Y, Li N, Zhang X, Gao Z, Zhang X, Liu Y, Zou J, Meng L

and 13 more — show all

Liu S, Zhu H, Tang X, Wu H, Su K, Chen B, Yu D, Ye H, Chen H, Yi H, Yin S, Guan J, Shi Y

American journal of respiratory and critical care medicine · 2022 · PMID 35819321

Questions about rs117949693

What is rs117949693?

rs117949693 is a single position in the genome, in or near the ANK1 gene. Published research associates it with non-supine apnea hypopnea index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs117949693 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs117949693 come from?

GWAS Catalog, American journal of respiratory and critical care medicine 2022, PMID:35819321. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Non-supine apnea hypopnea index (rs117949693). MyGeneLog™. https://www.mygenelog.com/variants/rs117949693

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