Preeclampsia or other maternal hypertension (maternal genotype effect)
TNS2 · rs117928258
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 15,200 European ancestry cases, 115,007 European ancestry controls.
The effect
Each copy of the T allele carried 1.45 times the odds of Preeclampsia or other maternal hypertension (maternal genotype effect) (95% confidence interval 1.32-1.6); p = 3 × 10−14.
How common The T allele had a frequency of about 2% in the people studied.
Where it sits Chromosome 12, band 12q13.13 — a synonymous change in TNS2.
What each result means
C/CNo copy of the version the research linked to Preeclampsia or other maternal hypertension (maternal genotype effect). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Preeclampsia or other maternal hypertension (maternal genotype effect). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Preeclampsia or other maternal hypertension (maternal genotype effect). That is the strongest link of the three results. A link in a study is not a diagnosis.
JAMA cardiology · 2023 · PMID 37285119 · open access
Questions about rs117928258
What is rs117928258?
rs117928258 is a single position in the genome, in or near the TNS2 gene. Published research associates it with preeclampsia or other maternal hypertension (maternal genotype effect). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs117928258 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs117928258 come from?
GWAS Catalog, JAMA cardiology 2023, PMID:37285119. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Preeclampsia or other maternal hypertension (maternal genotype effect) (rs117928258). MyGeneLog™. https://www.mygenelog.com/variants/rs117928258