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Alzheimer’s disease and/or vascular dementia (clinical subgroup VaD++)

CNTNAP2 · rs117834366

Where this position leads

Condition: Vascular Dementia

rs117834366 Condition: Vascular Dementia Vascular Dementia Condition rs117834366 rs117834366 CNTNAP2

What the study found

Who was studied 373 Spanish ancestry cases, 3,289 Spanish ancestry controls.

The effect Each copy of the A allele carried 6.03 times the odds of Alzheimer’s disease and/or vascular dementia (clinical subgroup VaD++) (95% confidence interval 3.22-11.2); p = 2 × 10−8.

How common The A allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 7, band 7q35 — in an intron of CNTNAP2.

What each result means

A/A Two copies of the version the research linked to Alzheimer’s disease and/or vascular dementia (clinical subgroup VaD++). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Alzheimer’s disease and/or vascular dementia (clinical subgroup VaD++). That is a smaller link than two copies.
G/G No copy of the version the research linked to Alzheimer’s disease and/or vascular dementia (clinical subgroup VaD++). This is the starting point the study compared everyone against.
Source
Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project
Moreno-Grau S, de Rojas I, Hernández I, Quintela I, Montrreal L, Alegret M, Hernández-Olasagarre B, Madrid L, González-Perez A, Maroñas O, Rosende-Roca M, Mauleón A
and 46 more — show all
Vargas L, Lafuente A, Abdelnour C, Rodríguez-Gómez O, Gil S, Santos-Santos MÁ, Espinosa A, Ortega G, Sanabria Á, Pérez-Cordón A, Cañabate P, Moreno M, Preckler S, Ruiz S, Aguilera N, Pineda JA, Macías J, Alarcón-Martín E, Sotolongo-Grau O, Marquié M, Monté-Rubio G, Valero S, Benaque A, Clarimón J, Bullido MJ, García-Ribas G, Pástor P, Sánchez-Juan P, Álvarez V, Piñol-Ripoll G, García-Alberca JM, Royo JL, Franco E, Mir P, Calero M, Medina M, Rábano A, Ávila J, Antúnez C, Real LM, Orellana A, Carracedo Á, Sáez ME, Tárraga L, Boada M, Ruiz A
GR@ACE consortium · DEGESCO consortium · Alzheimer's Disease Neuroimaging Initiative
Alzheimer's & dementia : the journal of the Alzheimer's Association · 2019 · PMID 31473137

Questions about rs117834366

What is rs117834366?

rs117834366 is a single position in the genome, in or near the CNTNAP2 gene. Published research associates it with alzheimer’s disease and/or vascular dementia (clinical subgroup vad++). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs117834366 linked to?

On MyGeneLog this position is linked to Vascular Dementia. The research behind each link, and its sources, are set out on that condition page.

Does having rs117834366 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs117834366 come from?

GWAS Catalog, Alzheimer's & dementia : the journal of the Alzheimer's Association 2019, PMID:31473137. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Alzheimer’s disease and/or vascular dementia (clinical subgroup VaD++) (rs117834366). MyGeneLog™. https://www.mygenelog.com/variants/rs117834366

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