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Carotid intima media thickness

ZHX2 · rs11781551

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied Up to 31,211 European ancestry individuals; replicated in 10,553 European ancestry individuals, 687 Orcadian individuals.

The effect Each copy of the A allele shifted the measure 0.0078 lower (95% confidence interval 0.01-0.01); p = 2 × 10⁻¹¹.

How common The A allele had a frequency of about 48% in the people studied.

Where it sits Chromosome 8, band 8q24.13 — between genes, 18.5 kb from SMILR.

What each result means

A/A Two copies of the version the research linked to Carotid intima media thickness. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Carotid intima media thickness. That is a smaller link than two copies.

G/G No copy of the version the research linked to Carotid intima media thickness. This is the starting point the study compared everyone against.

Source

Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque

Bis JC, Kavousi M, Franceschini N, Isaacs A, Abecasis GR, Schminke U, Post WS, Smith AV, Cupples LA, Markus HS, Schmidt R, Huffman JE

and 81 more — show all

Lehtimäki T, Baumert J, Münzel T, Heckbert SR, Dehghan A, North K, Oostra B, Bevan S, Stoegerer EM, Hayward C, Raitakari O, Meisinger C, Schillert A, Sanna S, Völzke H, Cheng YC, Thorsson B, Fox CS, Rice K, Rivadeneira F, Nambi V, Halperin E, Petrovic KE, Peltonen L, Wichmann HE, Schnabel RB, Dörr M, Parsa A, Aspelund T, Demissie S, Kathiresan S, Reilly MP, Taylor K, Uitterlinden A, Couper DJ, Sitzer M, Kähönen M, Illig T, Wild PS, Orru M, Lüdemann J, Shuldiner AR, Eiriksdottir G, White CC, Rotter JI, Hofman A, Seissler J, Zeller T, Usala G, Ernst F, Launer LJ, D'Agostino RB Sr, O'Leary DH, Ballantyne C, Thiery J, Ziegler A, Lakatta EG, Chilukoti RK, Harris TB, Wolf PA, Psaty BM, Polak JF, Li X, Rathmann W, Uda M, Boerwinkle E, Klopp N, Schmidt H, Wilson JF, Viikari J, Koenig W, Blankenberg S, Newman AB, Witteman J, Heiss G, Duijn Cv, Scuteri A, Homuth G, Mitchell BD, Gudnason V, O'Donnell CJ

CARDIoGRAM Consortium

Nature genetics · 2011 · PMID 21909108 · open access

Questions about rs11781551

What is rs11781551?

rs11781551 is a single position in the genome, in or near the ZHX2 gene. Published research associates it with carotid intima media thickness. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs11781551 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11781551 come from?

GWAS Catalog, Nature genetics 2011, PMID:21909108. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Carotid intima media thickness (rs11781551). MyGeneLog™. https://www.mygenelog.com/variants/rs11781551

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