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Multiple system atrophy

RABGEF1 · rs11766262

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 888 European ancestry cases, 7,128 European ancestry controls.

The effect Each copy of the C allele carried 1.95 times the odds of Multiple system atrophy (95% confidence interval 1.55-2.46); p = 2 × 10⁻⁸.

How common The C allele had a frequency of about 59% in the people studied.

Where it sits Chromosome 7, band 7q11.21 — in an intron of RABGEF1.

What each result means

C/C Two copies of the version the research linked to Multiple system atrophy. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Multiple system atrophy. That is a smaller link than two copies.

T/T No copy of the version the research linked to Multiple system atrophy. This is the starting point the study compared everyone against.

Source

Genome sequence analyses identify novel risk loci for multiple system atrophy

Chia R, Ray A, Shah Z, Ding J, Ruffo P, Fujita M, Menon V, Saez-Atienzar S, Reho P, Kaivola K, Walton RL, Reynolds RH

and 94 more — show all

Karra R, Sait S, Akcimen F, Diez-Fairen M, Alvarez I, Fanciulli A, Stefanova N, Seppi K, Duerr S, Leys F, Krismer F, Sidoroff V, Zimprich A, Pirker W, Rascol O, Foubert-Samier A, Meissner WG, Tison F, Pavy-Le Traon A, Pellecchia MT, Barone P, Russillo MC, Marín-Lahoz J, Kulisevsky J, Torres S, Mir P, Periñán MT, Proukakis C, Chelban V, Wu L, Goh YY, Parkkinen L, Hu MT, Kobylecki C, Saxon JA, Rollinson S, Garland E, Biaggioni I, Litvan I, Rubio I, Alcalay RN, Kwei KT, Lubbe SJ, Mao Q, Flanagan ME, Castellani RJ, Khurana V, Ndayisaba A, Calvo A, Mora G, Canosa A, Floris G, Bohannan RC, Moore A, Norcliffe-Kaufmann L, Palma JA, Kaufmann H, Kim C, Iba M, Masliah E, Dawson TM, Rosenthal LS, Pantelyat A, Albert MS, Pletnikova O, Troncoso JC, Infante J, Lage C, Sánchez-Juan P, Serrano GE, Beach TG, Pastor P, Morris HR, Albani D, Clarimon J, Wenning GK, Hardy JA, Ryten M, Topol E, Torkamani A, Chiò A, Bennett DA, De Jager PL, Low PA, Singer W, Cheshire WP, Wszolek ZK, Dickson DW, Traynor BJ, Gibbs JR, Dalgard CL, Ross OA, Houlden H, Scholz SW

Neuron · 2024 · PMID 38701790

Questions about rs11766262

What is rs11766262?

rs11766262 is a single position in the genome, in or near the RABGEF1 gene. Published research associates it with multiple system atrophy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs11766262 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11766262 come from?

GWAS Catalog, Neuron 2024, PMID:38701790. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Multiple system atrophy (rs11766262). MyGeneLog™. https://www.mygenelog.com/variants/rs11766262

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