Who was studied 17,151 European ancestry cases, 596,639 European ancestry controls.
The effect
Each copy of the C allele carried 1.26 times the odds of Osteoarthritis (hip) (95% confidence interval 1.17-1.36); p = 2 × 10−9.
Where it sits Chromosome 7, band 7p21.1 — in an intron of HDAC9.
What each result means
A/APublished research associates this genotype with typical/baseline likelihood of Osteoarthritis (hip) — no copies of the reported risk allele.
A/CPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Osteoarthritis (hip).
C/CPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Osteoarthritis (hip) compared to the general population.
rs11764536 is a single position in the genome, in or near the HDAC9 gene. Published research associates it with osteoarthritis (hip). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11764536 linked to?
On MyGeneLog this position is linked to Hip Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.
Does having rs11764536 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11764536 come from?
GWAS Catalog, Nat Genet 2018, PMID:30374069. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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