Sensitive

Post-traumatic stress disorder

near MAD1L1 · rs11760633

Where this position leads

Condition: Post-Traumatic Stress Disorder (PTSD)

What the study found

Who was studied 36,301 European ancestry cases, 178,107 European ancestry controls; replicated in 23,212 European ancestry cases, 151,447 European ancestry controls.

The effect The reported allele is T; the catalogue records no effect size ; p = 3 × 10⁻¹⁰.

How common The T allele had a frequency of about 16% in the people studied.

Where it sits Chromosome 7, band 7p22.3 — between genes, 2.7 kb from MAD1L1.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Post-traumatic stress disorder — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Post-traumatic stress disorder.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Post-traumatic stress disorder compared to the general population.

Source

Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program

Stein MB, Levey DF, Cheng Z, Wendt FR, Harrington K, Pathak GA, Cho K, Quaden R, Radhakrishnan K, Girgenti MJ, Ho YA, Posner D

and 6 more — show all

Aslan M, Duman RS, Zhao H, Polimanti R, Concato J, Gelernter J

Department of Veterans Affairs Cooperative Studies Program (no. 575B) · VA Million Veteran Program

Nature genetics · 2021 · PMID 33510476 · open access

Questions about rs11760633

What is rs11760633?

rs11760633 is a single position in the genome, in or near the near MAD1L1 gene. Published research associates it with post-traumatic stress disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11760633 linked to?

On MyGeneLog this position is linked to Post-Traumatic Stress Disorder (PTSD). The research behind each link, and its sources, are set out on that condition page.

Does having rs11760633 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11760633 come from?

GWAS Catalog, Nature genetics 2021, PMID:33510476. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Post-traumatic stress disorder (rs11760633). MyGeneLog™. https://www.mygenelog.com/variants/rs11760633

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