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Migraine without aura

FHL5 · rs11759769

Where this position leads

What the study found

Who was studied 7,107 European ancestry cases, 69,427 European ancestry controls.

The effect Each copy of the A allele carried 1.18 times the odds of Migraine without aura (95% confidence interval 1.13-1.24); p = 2 × 10⁻¹².

How common The A allele had a frequency of about 22% in the people studied.

Where it sits Chromosome 6, band 6q16.1 — in the 3′ untranslated region of FHL5.

What each result means

A/A Two copies of the version the research linked to Migraine without aura. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Migraine without aura. That is a smaller link than two copies.

G/G No copy of the version the research linked to Migraine without aura. This is the starting point the study compared everyone against.

Source

Genome-wide meta-analysis identifies new susceptibility loci for migraine

Anttila V, Winsvold BS, Gormley P, Kurth T, Bettella F, McMahon G, Kallela M, Malik R, de Vries B, Terwindt G, Medland SE, Todt U

and 85 more — show all

McArdle WL, Quaye L, Koiranen M, Ikram MA, Lehtimäki T, Stam AH, Ligthart L, Wedenoja J, Dunham I, Neale BM, Palta P, Hamalainen E, Schürks M, Rose LM, Buring JE, Ridker PM, Steinberg S, Stefansson H, Jakobsson F, Lawlor DA, Evans DM, Ring SM, Färkkilä M, Artto V, Kaunisto MA, Freilinger T, Schoenen J, Frants RR, Pelzer N, Weller CM, Zielman R, Heath AC, Madden PAF, Montgomery GW, Martin NG, Borck G, Göbel H, Heinze A, Heinze-Kuhn K, Williams FMK, Hartikainen AL, Pouta A, van den Ende J, Uitterlinden AG, Hofman A, Amin N, Hottenga JJ, Vink JM, Heikkilä K, Alexander M, Muller-Myhsok B, Schreiber S, Meitinger T, Wichmann HE, Aromaa A, Eriksson JG, Traynor B, Trabzuni D, Rossin E, Lage K, Jacobs SBR, Jacobs SBR, Gibbs JR, Birney E, Kaprio J, Penninx BW, Boomsma DI, van Duijn C, van Duijn C, Raitakari O, Jarvelin MR, Zwart JA, Cherkas L, Strachan DP, Kubisch C, Ferrari MD, van den Maagdenberg AMJM, Dichgans M, Wessman M, Smith GD, Stefansson K, Daly MJ, Nyholt DR, Chasman D, Palotie A

North American Brain Expression Consortium · UK Brain Expression Consortium

Nature genetics · 2013 · PMID 23793025 · open access

Questions about rs11759769

What is rs11759769?

rs11759769 is a single position in the genome, in or near the FHL5 gene. Published research associates it with migraine without aura. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11759769 linked to?

On MyGeneLog this position is linked to Migraine. The research behind each link, and its sources, are set out on that condition page.

Does having rs11759769 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11759769 come from?

GWAS Catalog, Nat Genet 2013, PMID:23793025. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Migraine without aura (rs11759769). MyGeneLog™. https://www.mygenelog.com/variants/rs11759769

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