Sensitive

Systemic lupus erythematosus

near HLA-DRB1 · rs11757382

Where this position leads

Condition: Systemic Lupus Erythematosus

rs11757382 Condition: Systemic Lupus Erythematosus Systemic Lupus Erythematosus Condition rs11757382 rs11757382 near HLA-DRB1

What the study found

Who was studied 16,491 European ancestry cases, 1,202,106 European ancestry controls.

The effect Each copy of the A allele shifted the measure 0.124 higher (95% confidence interval 0.08-0.169); p = 2 × 10−8.

Where it sits Chromosome 6, band 6p21.32 — between genes, 12 kb from HLA-DRB1.

What each result means

A/A Two copies of the version the research linked to Systemic lupus erythematosus. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to Systemic lupus erythematosus. That is a smaller link than two copies.
C/C No copy of the version the research linked to Systemic lupus erythematosus. This is the starting point the study compared everyone against.
Source

Questions about rs11757382

What is rs11757382?

rs11757382 is a single position in the genome, in or near the near HLA-DRB1 gene. Published research associates it with systemic lupus erythematosus. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11757382 linked to?

On MyGeneLog this position is linked to Systemic Lupus Erythematosus. The research behind each link, and its sources, are set out on that condition page.

Does having rs11757382 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11757382 come from?

GWAS Catalog, Mammalian genome : official journal of the International Mammalian Genome Society 2026, PMID:42581184. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Systemic lupus erythematosus (rs11757382). MyGeneLog™. https://www.mygenelog.com/variants/rs11757382

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