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Thyroid hormone levels

VEGFA · rs11755845

Where this position leads

Condition: Thyroid Stimulating Hormone (TSH) Levels

What the study found

Who was studied up to 14,459 European ancestry females, up to 10,936 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males.

The effect Each copy of the T allele shifted the measure 0.076 lower (95% confidence interval 0.047-0.105); p = 3 × 10⁻⁷.

How common The T allele had a frequency of about 27% in the people studied.

Where it sits Chromosome 6, band 6p21.1 — in a non-coding transcript of SCIRT.

What each result means

C/C No copy of the version the research linked to Thyroid hormone levels. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Thyroid hormone levels. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Thyroid hormone levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function

Porcu E, Medici M, Pistis G, Volpato CB, Wilson SG, Cappola AR, Bos SD, Deelen J, den Heijer M, Freathy RM, Lahti J, Liu C

and 82 more — show all

Lopez LM, Nolte IM, O'Connell JR, Tanaka T, Trompet S, Arnold A, Bandinelli S, Beekman M, Böhringer S, Brown SJ, Buckley BM, Camaschella C, de Craen AJ, Davies G, de Visser MC, Ford I, Forsen T, Frayling TM, Fugazzola L, Gögele M, Hattersley AT, Hermus AR, Hofman A, Houwing-Duistermaat JJ, Jensen RA, Kajantie E, Kloppenburg M, Lim EM, Masciullo C, Mariotti S, Minelli C, Mitchell BD, Nagaraja R, Netea-Maier RT, Palotie A, Persani L, Piras MG, Psaty BM, Räikkönen K, Richards JB, Rivadeneira F, Sala C, Sabra MM, Sattar N, Shields BM, Soranzo N, Starr JM, Stott DJ, Sweep FC, Usala G, van der Klauw MM, van Heemst D, van Mullem A, Vermeulen SH, Visser WE, Walsh JP, Westendorp RG, Widen E, Zhai G, Cucca F, Deary IJ, Eriksson JG, Ferrucci L, Fox CS, Jukema JW, Kiemeney LA, Pramstaller PP, Schlessinger D, Shuldiner AR, Slagboom EP, Uitterlinden AG, Vaidya B, Visser TJ, Wolffenbuttel BH, Meulenbelt I, Rotter JI, Spector TD, Hicks AA, Toniolo D, Sanna S, Peeters RP, Naitza S

PLoS genetics · 2013 · PMID 23408906 · open access

Questions about rs11755845

What is rs11755845?

rs11755845 is a single position in the genome, in or near the VEGFA gene. Published research associates it with thyroid hormone levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11755845 linked to?

On MyGeneLog this position is linked to Thyroid Stimulating Hormone (TSH) Levels. The research behind each link, and its sources, are set out on that condition page.

Does having rs11755845 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11755845 come from?

GWAS Catalog, PLoS Genet 2013, PMID:23408906. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Thyroid hormone levels (rs11755845). MyGeneLog™. https://www.mygenelog.com/variants/rs11755845

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