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Insulin-like growth factor 1 levels

PRKCA · rs117524772

Where this position leads

Condition: Gout

What the study found

Who was studied 340,567 European ancestry individuals, 5,974 African ancestry individuals, 7,283 South Asian ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0646 higher (95% confidence interval 0.05-0.079); p = 1 × 10⁻¹⁷.

Where it sits Chromosome 17, band 17q24.2 — in an intron of PRKCA.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Insulin-like growth factor 1 levels compared to the general population.

A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Insulin-like growth factor 1 levels.

C/C Published research associates this genotype with typical/baseline likelihood of Insulin-like growth factor 1 levels — no copies of the reported risk allele.

Source

Genetics of 35 blood and urine biomarkers in the UK Biobank

Sinnott-Armstrong N, Tanigawa Y, Amar D, Mars N, Benner C, Aguirre M, Venkataraman GR, Wainberg M, Ollila HM, Kiiskinen T, Havulinna AS, Pirruccello JP

and 11 more — show all

Qian J, Shcherbina A, Rodriguez F, Assimes TL, Agarwala V, Tibshirani R, Hastie T, Ripatti S, Pritchard JK, Daly MJ, Rivas MA

FinnGen

Nature genetics · 2021 · PMID 33462484 · open access

Questions about rs117524772

What is rs117524772?

rs117524772 is a single position in the genome, in or near the PRKCA gene. Published research associates it with insulin-like growth factor 1 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs117524772 linked to?

On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.

Does having rs117524772 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs117524772 come from?

GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Insulin-like growth factor 1 levels (rs117524772). MyGeneLog™. https://www.mygenelog.com/variants/rs117524772

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