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Neonatal circulating Complement Component 4 (C4) protein concentration

VARS1 · rs11751198

What the study found

Who was studied 68,768 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.39 higher (95% confidence interval 0.35-0.43); p = 8 × 10−145.

Where it sits Chromosome 6, band 6p21.33 — inside VARS1.

What each result means

A/A Two copies of the version the research linked to Neonatal circulating Complement Component 4 (C4) protein concentration. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Neonatal circulating Complement Component 4 (C4) protein concentration. That is a smaller link than two copies.
G/G No copy of the version the research linked to Neonatal circulating Complement Component 4 (C4) protein concentration. This is the starting point the study compared everyone against.
Source

Questions about rs11751198

What is rs11751198?

rs11751198 is a single position in the genome, in or near the VARS1 gene. Published research associates it with neonatal circulating complement component 4 (c4) protein concentration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs11751198 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11751198 come from?

GWAS Catalog, Cell genomics 2023, PMID:38116117. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Neonatal circulating Complement Component 4 (C4) protein concentration (rs11751198). MyGeneLog™. https://www.mygenelog.com/variants/rs11751198

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