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Resistant hypertension

MSX2 · rs11749255

Where this position leads

Condition: Resistant Hypertension

rs11749255 Condition: Resistant Hypertension Resistant Hypertension Condition rs11749255 rs11749255 MSX2

What the study found

Who was studied 226 European ancestry cases, 143 Hispanic cases, 431 European ancestry controls, 394 Hispanic controls; replicated in 71 European ancestry cases, 83 Hispanic cases, 192 European ancestry controls, 239 Hispanic controls.

The effect Each copy of the A allele carried 1.60 times the odds of Resistant hypertension (95% confidence interval 1.30-1.90); p = 4 × 10−8.

Where it sits Chromosome 5, band 5q35.2 — between genes, 9.5 kb from HIGD1AP3.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Resistant hypertension compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Resistant hypertension.
G/G Published research associates this genotype with typical/baseline likelihood of Resistant hypertension — no copies of the reported risk allele.
Source
Genome-wide association analysis of common genetic variants of resistant hypertension
El Rouby N, McDonough CW, Gong Y, McClure LA, Mitchell BD, Horenstein RB, Talbert RL, Crawford DC, Gitzendanner MA, Takahashi A, Tanaka T, Kubo M
and 5 more — show all
Pepine CJ, Cooper-DeHoff RM, Benavente OR, Shuldiner AR, Johnson JA
eMERGE network
The pharmacogenomics journal · 2019 · PMID 30237584

Questions about rs11749255

What is rs11749255?

rs11749255 is a single position in the genome, in or near the MSX2 gene. Published research associates it with resistant hypertension. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11749255 linked to?

On MyGeneLog this position is linked to Resistant Hypertension. The research behind each link, and its sources, are set out on that condition page.

Does having rs11749255 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11749255 come from?

GWAS Catalog, Pharmacogenomics J 2018, PMID:30237584. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Resistant hypertension (rs11749255). MyGeneLog™. https://www.mygenelog.com/variants/rs11749255

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