Severe COVID-19 or systemic lupus erythematosus (inverse variance)
RGL1 · rs1174683
0 81124Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others4Total8Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 6,956 European ancestry severe COVID-19 cases, 1,823 severe COVID-19 cases, 9,302 European ancestry SLE cases, 1,024,729 European ancestry controls, 328,311 controls.
The effect
Each copy of the G allele carried 1.16 times the odds of Severe COVID-19 or systemic lupus erythematosus (inverse variance) (95% confidence interval 1.11-1.22); p = 2 × 10−9.
Where it sits Chromosome 1, band 1q25.3 — in an intron of RGL1.
What each result means
A/ANo copy of the version the research linked to Severe COVID-19 or systemic lupus erythematosus (inverse variance). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Severe COVID-19 or systemic lupus erythematosus (inverse variance). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Severe COVID-19 or systemic lupus erythematosus (inverse variance). That is the strongest link of the three results. A link in a study is not a diagnosis.
PLoS genetics · 2022 · PMID 36327221 · open access
Questions about rs1174683
What is rs1174683?
rs1174683 is a single position in the genome, in or near the RGL1 gene. Published research associates it with severe covid-19 or systemic lupus erythematosus (inverse variance). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1174683 linked to?
On MyGeneLog this position is linked to Systemic Lupus Erythematosus. The research behind each link, and its sources, are set out on that condition page.
Does having rs1174683 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1174683 come from?
GWAS Catalog, PLoS genetics 2022, PMID:36327221. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 81124Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others4Total8Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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Severe COVID-19 or systemic lupus erythematosus (inverse variance) (rs1174683). MyGeneLog™. https://www.mygenelog.com/variants/rs1174683