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Who was studied 394,642 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.0984 lower (95% confidence interval 0.068-0.129); p = 1 × 10−11.
How common The C allele had a frequency of about 0% in the people studied.
Where it sits Chromosome 12, band 12q24.13 — in an intron of HECTD4.
What each result means
C/CTwo copies of the version the research linked to Platelet crit (UKB data field 30090). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Platelet crit (UKB data field 30090). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Platelet crit (UKB data field 30090). This is the starting point the study compared everyone against.
Nature genetics · 2025 · PMID 39789286 · open access
Questions about rs117447866
What is rs117447866?
rs117447866 is a single position in the genome, in or near the HECTD4 gene. Published research associates it with platelet crit (ukb data field 30090). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs117447866 linked to?
On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs117447866 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs117447866 come from?
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 91332Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot3Amazon3Apple0China (ByteDance, Huawei, Baidu…)0Others2Total9Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Platelet crit (UKB data field 30090) (rs117447866). MyGeneLog™. https://www.mygenelog.com/variants/rs117447866