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Cholesteryl ester transfer protein levels

CETP · rs117427818

Where this position leads

Drug: Statins

rs117427818 Drug: Statins Statins Drug rs117427818 rs117427818 CETP

What the study found

Who was studied 4248 individuals; replicated in 1458 individuals.

The effect Each copy of the T allele shifted the measure 0.46 µg/mL higher (95% confidence interval 0.39-0.53); p = 3 × 10−33.

How common The T allele had a frequency of about 5% in the people studied.

Where it sits Chromosome 16, band 16q13 — in an intron of CETP.

What each result means

C/C No copy of the version the research linked to Cholesteryl ester transfer protein levels. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Cholesteryl ester transfer protein levels. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Cholesteryl ester transfer protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs117427818

What is rs117427818?

rs117427818 is a single position in the genome, in or near the CETP gene. Published research associates it with cholesteryl ester transfer protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs117427818 affect how medicines work?

CETP carries pharmacogenomic findings for Statins. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs117427818 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs117427818 come from?

GWAS Catalog, Circ Genom Precis Med 2018, PMID:29728394. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Cholesteryl ester transfer protein levels (rs117427818). MyGeneLog™. https://www.mygenelog.com/variants/rs117427818

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