Gene Knowledge Graph
Gene Knowledge Graph UTC
Sensitive

Bipolar disorder

FAM196B · rs11742527

Where this position leads

Condition: Bipolar Disorder

rs11742527 Condition: Bipolar Disorder Bipolar Disorder Condition rs11742527 rs11742527 FAM196B

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Bipolar disorder — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Bipolar disorder.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Bipolar disorder compared to the general population.
Source
Genome-Wide Association Studies of Schizophrenia and Bipolar Disorder in a Diverse Cohort of US Veterans
Bigdeli TB, Fanous AH, Li Y, Rajeevan N, Sayward F, Genovese G, Gupta R, Radhakrishnan K, Malhotra AK, Sun N, Lu Q, Hu Y
and 33 more — show all
Li B, Chen Q, Mane S, Miller P, Cheung KH, Gur RE, Greenwood TA, Braff DL, Achtyes ED, Buckley PF, Escamilla MA, Lehrer D, Malaspina DP, McCarroll SA, Rapaport MH, Vawter MP, Pato MT, Pato CN, Zhao H, Kosten TR, Brophy M, Pyarajan S, Shi Y, O'Leary TJ, Gleason T, Przygodzki R, Muralidhar S, Gaziano JM, Huang GD, Concato J, Siever LJ, Aslan M, Harvey PD
Consortium on the Genetics of Schizophrenia (COGS) · Genomic Psychiatry Cohort (GPC) Investigators · Million Veteran Program (MVP)
Schizophrenia bulletin · 2021 · PMID 33169155

Questions about rs11742527

What is rs11742527?

rs11742527 is a single position in the genome, in or near the FAM196B gene. Published research associates it with bipolar disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11742527 linked to?

On MyGeneLog this position is linked to Bipolar Disorder. The research behind each link, and its sources, are set out on that condition page.

Does having rs11742527 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11742527 come from?

GWAS Catalog, Schizophr Bull 2020, PMID:33169155. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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