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Pediatric autoimmune diseases

IL5 · rs11741255

Where this position leads

Condition: Ulcerative Colitis

rs11741255 Condition: Ulcerative Colitis Ulcerative Colitis Condition rs11741255 rs11741255 IL5

What the study found

Who was studied 97 European ancestry thyroiditis cases, 107 European ancestry ankylosing spondylitis cases, 100 European ancestry psoriasis cases, 173 European ancestry celiac disease cases, 254 European ancestry systemic lupus erythematosus cases, 308 European ancestry common variable inmunodeficiency cases, 865 European ancestry ulcerative colitis cases, 1,086 European ancestry Type 1 diabetes cases, 1,123 European ancestry juvenile idiopathic arthritis cases, 1,922 European ancestry Crohn's disease cases, 10,718 European ancestry controls.

The effect The reported allele is A; the catalogue records no effect size ; p = 2 × 10−9.

How common The A allele had a frequency of about 42% in the people studied.

Where it sits Chromosome 5, band 5q31.1 — in an intron of IRF1.

What each result means

A/A Two copies of the version the research linked to Pediatric autoimmune diseases. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Pediatric autoimmune diseases. That is a smaller link than two copies.
G/G No copy of the version the research linked to Pediatric autoimmune diseases. This is the starting point the study compared everyone against.
Source
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases
Li YR, Li J, Zhao SD, Bradfield JP, Mentch FD, Maggadottir SM, Hou C, Abrams DJ, Chang D, Gao F, Guo Y, Wei Z
and 54 more — show all
Connolly JJ, Cardinale CJ, Bakay M, Glessner JT, Li D, Kao C, Thomas KA, Qiu H, Chiavacci RM, Kim CE, Wang F, Snyder J, Richie MD, Flatø B, Førre Ø, Denson LA, Thompson SD, Becker ML, Guthery SL, Latiano A, Perez E, Resnick E, Russell RK, Wilson DC, Silverberg MS, Annese V, Lie BA, Punaro M, Dubinsky MC, Monos DS, Strisciuglio C, Staiano A, Miele E, Kugathasan S, Ellis JA, Munro JE, Sullivan KE, Wise CA, Chapel H, Cunningham-Rundles C, Grant SF, Orange JS, Sleiman PM, Behrens EM, Griffiths AM, Satsangi J, Finkel TH, Keinan A, Prak ET, Polychronakos C, Baldassano RN, Li H, Keating BJ, Hakonarson H
Nature medicine · 2015 · PMID 26301688

Questions about rs11741255

What is rs11741255?

rs11741255 is a single position in the genome, in or near the IL5 gene. Published research associates it with pediatric autoimmune diseases. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11741255 linked to?

On MyGeneLog this position is linked to Ulcerative Colitis. The research behind each link, and its sources, are set out on that condition page.

Does having rs11741255 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11741255 come from?

GWAS Catalog, Nat Med 2015, PMID:26301688. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Pediatric autoimmune diseases (rs11741255). MyGeneLog™. https://www.mygenelog.com/variants/rs11741255

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