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Survival in sporadic amyotrophic lateral sclerosis

FGF1 · rs11738209

Where this position leads

Condition: Amyotrophic Lateral Sclerosis

rs11738209 Condition: Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis Condition rs11738209 rs11738209 FGF1

What the study found

Who was studied 1,076 Japanese ancestry individuals.

The effect Each copy of the A allele carried 2.36 times the odds of Survival in sporadic amyotrophic lateral sclerosis (95% confidence interval 1.77-3.15); p = 5 × 10−9.

How common The A allele had a frequency of about 3% in the people studied.

Where it sits Chromosome 5, band 5q31.3 — in an intron of FGF1.

What each result means

A/A Two copies of the version the research linked to Survival in sporadic amyotrophic lateral sclerosis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/T One copy of the version the research linked to Survival in sporadic amyotrophic lateral sclerosis. That is a smaller link than two copies.
T/T No copy of the version the research linked to Survival in sporadic amyotrophic lateral sclerosis. This is the starting point the study compared everyone against.
Source
Genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis: a genome-wide association study and verification in iPSC-derived motor neurons from patients
Nakamura R, Tohnai G, Nakatochi M, Atsuta N, Watanabe H, Ito D, Katsuno M, Hirakawa A, Izumi Y, Morita M, Hirayama T, Kano O
and 37 more — show all
Kanai K, Hattori N, Taniguchi A, Suzuki N, Aoki M, Iwata I, Yabe I, Shibuya K, Kuwabara S, Oda M, Hashimoto R, Aiba I, Ishihara T, Onodera O, Yamashita T, Abe K, Mizoguchi K, Shimizu T, Ikeda Y, Yokota T, Hasegawa K, Tanaka F, Nakashima K, Kaji R, Niwa JI, Doyu M, Terao C, Ikegawa S, Fujimori K, Nakamura S, Ozawa F, Morimoto S, Onodera K, Ito T, Okada Y, Okano H, Sobue G
Japanese Consortium for Amyotrophic Lateral Sclerosis research (JaCALS) study group
Journal of neurology, neurosurgery, and psychiatry · 2023 · PMID 37142397

Questions about rs11738209

What is rs11738209?

rs11738209 is a single position in the genome, in or near the FGF1 gene. Published research associates it with survival in sporadic amyotrophic lateral sclerosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11738209 linked to?

On MyGeneLog this position is linked to Amyotrophic Lateral Sclerosis. The research behind each link, and its sources, are set out on that condition page.

Does having rs11738209 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11738209 come from?

GWAS Catalog, Journal of neurology, neurosurgery, and psychiatry 2023, PMID:37142397. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Survival in sporadic amyotrophic lateral sclerosis (rs11738209). MyGeneLog™. https://www.mygenelog.com/variants/rs11738209

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