LRBA · rs11737450
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 38,175 European ancestry individuals, 5,310 East Asian ancestry individuals.
The effect Each copy of the T allele shifted the measure 0.06 lower (95% confidence interval 0.04-0.08); p = 8 × 10−16.
How common The T allele had a frequency of about 25% in the people studied.
Where it sits Chromosome 4, band 4q31.3 — in an intron of LRBA.
What ClinVar records
Classification
Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 3 submitters), last evaluated 2023-11-12.
ClinVar record 1280628 NM_001364905.1(LRBA):c.7630+31G>A
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs11737450 is a single position in the genome, in or near the LRBA gene. Published research associates it with hip shape mode 10. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Human molecular genetics 2025, PMID:39574169. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Hip shape mode 10 (rs11737450). MyGeneLog™. https://www.mygenelog.com/variants/rs11737450