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Lung cancer

PDS5B · rs117371643

Where this position leads

Condition: Lung Cancer

rs117371643 Condition: Lung Cancer Lung Cancer Condition rs117371643 rs117371643 PDS5B

What the study found

Who was studied 59,774 European ancestry cases, 1,416,415 European ancestry controls, 11,773 East Asian ancestry cases, 288,419 East Asian ancestry controls, 4,782 African ancestry cases, 122,496 African ancestry controls, 624 Hispanic/Latino American ancestry cases, 59,042 Hispanic/Latino American ancestry controls.

The effect Each copy of the A allele shifted the measure 0.19 higher (95% confidence interval 0.13-0.25); p = 3 × 10−10.

How common The A allele had a frequency of about 2% in the people studied.

Where it sits Chromosome 13, band 13q13.1 — in an intron of PDS5B.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Lung cancer compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Lung cancer.
G/G Published research associates this genotype with typical/baseline likelihood of Lung cancer — no copies of the reported risk allele.
Source
Development and validation of a multiancestry and multitrait polygenic risk score for lung cancer
Zhang Y, Dai J, Gu P, Zhao Y, Christiani DC, Chen F, Shen S
Nature communications · 2026 · PMID 42364979 · open access

Questions about rs117371643

What is rs117371643?

rs117371643 is a single position in the genome, in or near the PDS5B gene. Published research associates it with lung cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs117371643 linked to?

On MyGeneLog this position is linked to Lung Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs117371643 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs117371643 come from?

GWAS Catalog, Nature communications 2026, PMID:42364979. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Lung cancer (rs117371643). MyGeneLog™. https://www.mygenelog.com/variants/rs117371643

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