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Who was studied 446,237 European ancestry individuals; replicated in 7,612 African ancestry individuals, 10,095 South Asian ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.0282 lower (95% confidence interval 0.02-0.036); p = 2 × 10−11.
How common The G allele had a frequency of about 98% in the people studied.
Where it sits Chromosome 19, band 19q13.2 — between genes, 8 kb from CYP2A6.
What each result means
A/ANo copy of the version the research linked to Urinary sodium excretion. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Urinary sodium excretion. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Urinary sodium excretion. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2019 · PMID 31409800 · open access
Questions about rs117287096
What is rs117287096?
rs117287096 is a single position in the genome, in or near the CYP2A6 gene. Published research associates it with urinary sodium excretion. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does rs117287096 affect how medicines work?
CYP2A6 carries pharmacogenomic findings for Smoking cessation medicines. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs117287096 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs117287096 come from?
GWAS Catalog, Nature communications 2019, PMID:31409800. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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