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Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.
The effect
Each copy of the G allele shifted the measure 0.02 mmol/L lower (95% confidence interval 0.02-0.02); p = 2 × 10−12.
Where it sits Chromosome 4, band 4q24 — in an intron of TET2.
What each result means
A/ANo copy of the version the research linked to Glucose levels. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Glucose levels. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Glucose levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2025 · PMID 41044249 · open access
Questions about rs11728350
What is rs11728350?
rs11728350 is a single position in the genome, in or near the TET2 gene. Published research associates it with glucose levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11728350 linked to?
On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.
Does having rs11728350 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11728350 come from?
GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 112315Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others5Total11Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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