Sensitive

Multiple sclerosis

CLEC16A · rs117283010

Where this position leads

What the study found

Who was studied 19,865 European ancestry cases, 623,043 European ancestry controls.

The effect Each copy of the A allele carried 1.13 times the odds of Multiple sclerosis (95% confidence interval 1.1-1.16); p = 3 × 10⁻¹⁶.

How common The A allele had a frequency of about 6% in the people studied.

Where it sits Chromosome 16, band 16p13.13 — in an intron of CLEC16A.

What each result means

A/A Two copies of the version the research linked to Multiple sclerosis. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Multiple sclerosis. That is a smaller link than two copies.

G/G No copy of the version the research linked to Multiple sclerosis. This is the starting point the study compared everyone against.

Source

Genome-wide association analyses highlight the neuronal contribution to multiple sclerosis susceptibility

Zeng L, Khan A, Fitzgerald KC, Lama T, Chen J, Li R, Tsai EA, Yu K, Chitnis T, Weiner HL, Le Grand Q, Debette S

and 7 more — show all

Wang G, Fujita M, Calabresi PA, Zipp F, Taga M, Kiryluk K, De Jager PL

International Multiple Sclerosis Genetics Consortium

Nature genetics · 2026 · PMID 42706309

In the news

2026-09-07 · Zeng L, et al. Nature Genetics 2026, PMID:42706309

Genome-wide association analyses highlight the neuronal contribution to multiple sclerosis susceptibility

The GWAS Catalog has added a study by Zeng L, et al. in Nature Genetics (2026): 178 associations across 1 trait ("Multiple sclerosis"). Sample in the catalogue's record: 19,865 cases and 623,043 controls. This site already has 70 of its 178 positions — 57 on the Multiple Sclerosis page; 2 on the Type 1 Diabetes page; 1 on the Rheumatoid Arthritis page — including rs12722559 (IL2RA), rs11809700 (EVI5), rs117283010 (CLEC16A). Put together by code from the catalogue's records; for anything more, follow the link to the paper. PMID:42706309.

Questions about rs117283010

What is rs117283010?

rs117283010 is a single position in the genome, in or near the CLEC16A gene. Published research associates it with multiple sclerosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs117283010 linked to?

On MyGeneLog this position is linked to Multiple Sclerosis. The research behind each link, and its sources, are set out on that condition page.

Does having rs117283010 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs117283010 come from?

GWAS Catalog, Nature genetics 2026, PMID:42706309. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Multiple sclerosis (rs117283010). MyGeneLog™. https://www.mygenelog.com/variants/rs117283010

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