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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 327,435 European ancestry individuals, 5,845 African ancestry individuals, 6,425 South Asian ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.0499 higher (95% confidence interval 0.035-0.065); p = 4 × 10−11.
Where it sits Chromosome 11, band 11p15.2 — in an intron of SPON1.
What each result means
C/CPublished research associates this genotype with typical/baseline likelihood of Vitamin D levels — no copies of the reported risk allele.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Vitamin D levels.
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Vitamin D levels compared to the general population.
Nature genetics · 2021 · PMID 33462484 · open access
Questions about rs117277599
What is rs117277599?
rs117277599 is a single position in the genome, in or near the SPON1 gene. Published research associates it with vitamin d levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs117277599 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs117277599 come from?
GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Vitamin D levels (rs117277599). MyGeneLog™. https://www.mygenelog.com/variants/rs117277599