Who was studied 11,157 European ancestry cases, 36,699 European ancestry controls, 1,142 African American cases, 2,380 African American controls, 199 Korean ancestry cases, 6,741 Korean ancestry controls, 52 Hispanic cases, 548 Hispanic controls.; replicated in 12,051 European ancestry cases, 11,111 European ancestry controls, 153 Korean ancestry cases, 205 Korean ancestry controls..
The effect
Each copy of the A allele carried 1.26 times the odds of Chronic obstructive pulmonary disease (95% confidence interval 1.18-1.33); p = 4 × 10−14.
How common The A allele had a frequency of about 94% in the people studied.
Where it sits Chromosome 4, band 4q24 — in an intron of GSTCD.
What each result means
A/APublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Chronic obstructive pulmonary disease compared to the general population.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Chronic obstructive pulmonary disease.
G/GPublished research associates this genotype with typical/baseline likelihood of Chronic obstructive pulmonary disease — no copies of the reported risk allele.
rs11727735 is a single position in the genome, in or near the NPNT gene. Published research associates it with chronic obstructive pulmonary disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11727735 linked to?
On MyGeneLog this position is linked to Chronic Obstructive Pulmonary Disease (COPD). The research behind each link, and its sources, are set out on that condition page.
Does having rs11727735 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11727735 come from?
GWAS Catalog, Nat Genet 2017, PMID:28166215. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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