Sensitive

Plasma norclozapine levels in treatment-resistant schizophrenia

UGT2B10 · rs11725502

Where this position leads

Condition: Schizophrenia

rs11725502 Condition: Schizophrenia Schizophrenia Condition rs11725502 rs11725502 UGT2B10

What the study found

Who was studied 2,989 European ancestry individuals.

The effect The reported allele is T; the catalogue records no effect size ; p = 5 × 10−15.

How common The T allele had a frequency of about 10% in the people studied.

Where it sits Chromosome 4, band 4q13.2 — between genes, 0.7 kb from UGT2B10.

What each result means

A/A No copy of the version the research linked to Plasma norclozapine levels in treatment-resistant schizophrenia. This is the starting point the study compared everyone against.
A/T One copy of the version the research linked to Plasma norclozapine levels in treatment-resistant schizophrenia. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Plasma norclozapine levels in treatment-resistant schizophrenia. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs11725502

What is rs11725502?

rs11725502 is a single position in the genome, in or near the UGT2B10 gene. Published research associates it with plasma norclozapine levels in treatment-resistant schizophrenia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11725502 linked to?

On MyGeneLog this position is linked to Schizophrenia. The research behind each link, and its sources, are set out on that condition page.

Does having rs11725502 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11725502 come from?

GWAS Catalog, The American journal of psychiatry 2019, PMID:30922102. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Plasma norclozapine levels in treatment-resistant schizophrenia (rs11725502). MyGeneLog™. https://www.mygenelog.com/variants/rs11725502

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