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CD38 on IgD+ CD38dim B cell

CD38 · rs11724146

What the study found

Who was studied 3,654 Sardinian (founder/genetic isolate) ancestry individuals.

The effect Each copy of the G allele shifted the measure 1.33 lower (95% confidence interval 1.17-1.49); p = 1 × 10−56.

How common The G allele had a frequency of about 2% in the people studied.

Where it sits Chromosome 4, band 4p15.32 — in an intron of CD38.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of CD38 on IgD+ CD38dim B cell — no copies of the reported risk allele.
C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with CD38 on IgD+ CD38dim B cell.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of CD38 on IgD+ CD38dim B cell compared to the general population.
Source

Questions about rs11724146

What is rs11724146?

rs11724146 is a single position in the genome, in or near the CD38 gene. Published research associates it with cd38 on igd+ cd38dim b cell. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs11724146 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11724146 come from?

GWAS Catalog, Nature genetics 2020, PMID:32929287. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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CD38 on IgD+ CD38dim B cell (rs11724146). MyGeneLog™. https://www.mygenelog.com/variants/rs11724146

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