Sensitive

Lung disease severity in cystic fibrosis

HLA-DRA · rs117230773

Where this position leads

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Lung disease severity in cystic fibrosis compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Lung disease severity in cystic fibrosis.

G/G Published research associates this genotype with typical/baseline likelihood of Lung disease severity in cystic fibrosis — no copies of the reported risk allele.

Source

Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis

Corvol H, Blackman SM, Boëlle PY, Gallins PJ, Pace RG, Stonebraker JR, Accurso FJ, Clement A, Collaco JM, Dang H, Dang AT, Franca A

and 19 more — show all

Gong J, Guillot L, Keenan K, Li W, Lin F, Patrone MV, Raraigh KS, Sun L, Zhou YH, O'Neal WK, Sontag MK, Levy H, Durie PR, Rommens JM, Drumm ML, Wright FA, Strug LJ, Cutting GR, Knowles MR

Nature communications · 2015 · PMID 26417704 · open access

Questions about rs117230773

What is rs117230773?

rs117230773 is a single position in the genome, in or near the HLA-DRA gene. Published research associates it with lung disease severity in cystic fibrosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs117230773 linked to?

On MyGeneLog this position is linked to Cystic Fibrosis. The research behind each link, and its sources, are set out on that condition page.

Does having rs117230773 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs117230773 come from?

GWAS Catalog, Nat Commun 2015, PMID:26417704. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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