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Urate levels

SLC2A9 · rs11722228

Where this position leads

Condition: Gout

rs11722228 Condition: Gout Gout Condition Topic: Blood sugar and insulin Blood sugar and insulin Topic Topic: Kidneys Kidneys Topic rs11722228 rs11722228 SLC2A9

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 8,868 Japanese ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.164 higher (95% confidence interval 0.13-0.2); p = 7 × 10−24.

How common The T allele had a frequency of about 45% in the people studied.

Where it sits Chromosome 4, band 4p16.1 — in an intron of SLC2A9.

What each result means

C/C No copy of the version the research linked to Urate levels. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Urate levels. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Urate levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Genome-wide association study of hematological and biochemical traits in a Japanese population
Kamatani Y, Matsuda K, Okada Y, Kubo M, Hosono N, Daigo Y, Nakamura Y, Kamatani N
Nature genetics · 2010 · PMID 20139978

What people read about alongside this

Blood sugar and insulin3 Kidneys3 Alcohol and the flush1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs11722228

What is rs11722228?

rs11722228 is a single position in the genome, in or near the SLC2A9 gene. Published research associates it with urate levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11722228 linked to?

On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs11722228?

Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (3 papers), kidneys (3 papers), alcohol and the flush (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs11722228 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11722228 come from?

GWAS Catalog, Nat Genet 2010, PMID:20139978. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Urate levels (rs11722228). MyGeneLog™. https://www.mygenelog.com/variants/rs11722228

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