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Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 2,619 Korean ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.368 higher; p = 2 × 10−8.
Where it sits Chromosome 10, band 10q21.3 — in an intron of CTNNA3.
What each result means
A/ANo copy of the version the research linked to Weight. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Weight. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Weight. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs117157743 is a single position in the genome, in or near the CTNNA3 gene. Published research associates it with weight. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs117157743 linked to?
On MyGeneLog this position is linked to Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.
Does having rs117157743 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs117157743 come from?
GWAS Catalog, GigaScience 2024, PMID:38626723. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 44Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others4Total4Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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