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Total cholesterol levels

KIF13B · rs117139027

What the study found

Who was studied 1,320,016 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.067 lower (95% confidence interval 0.055-0.079); p = 5 × 10−19.

How common The A allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 8, band 8p12 — a missense change in KIF13B.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Total cholesterol levels compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Total cholesterol levels.
G/G Published research associates this genotype with typical/baseline likelihood of Total cholesterol levels — no copies of the reported risk allele.
Source

Questions about rs117139027

What is rs117139027?

rs117139027 is a single position in the genome, in or near the KIF13B gene. Published research associates it with total cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs117139027 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs117139027 come from?

GWAS Catalog, Nature 2021, PMID:34887591. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Total cholesterol levels (rs117139027). MyGeneLog™. https://www.mygenelog.com/variants/rs117139027

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