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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 650 Amish individuals; replicated in 847 European American ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.916 higher; p = 4 × 10−11.
How common The T allele had a frequency of about 4% in the people studied.
Where it sits Chromosome 11, band 11q12.3 — in an intron of SLC22A25.
What each result means
C/CPublished research associates this genotype with typical/baseline likelihood of Estriol levels — no copies of the reported risk allele.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Estriol levels.
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Estriol levels compared to the general population.
Communications biology · 2022 · PMID 35393526 · open access
Questions about rs117070489
What is rs117070489?
rs117070489 is a single position in the genome, in or near the SLC22A25 gene. Published research associates it with estriol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs117070489 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs117070489 come from?
GWAS Catalog, Communications biology 2022, PMID:35393526. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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