Ticagrelor levels in individuals with acute coronary syndromes treated with ticagrelor
STAG3 · rs117038461
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Who was studied 1,794 European ancestry cases, 18 African and Asian ancestry cases; replicated in 1,922 European ancestry cases, 19 African and Asian ancestry cases.
The effect
Each copy of the C allele shifted the measure 0.232 higher (95% confidence interval 0.16-0.31); p = 9 × 10−10.
How common The C allele had a frequency of about 2% in the people studied.
Where it sits Chromosome 7, band 7q22.1 — in an intron of CASTOR3P.
What each result means
C/CTwo copies of the version the research linked to Ticagrelor levels in individuals with acute coronary syndromes treated with ticagrelor. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Ticagrelor levels in individuals with acute coronary syndromes treated with ticagrelor. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Ticagrelor levels in individuals with acute coronary syndromes treated with ticagrelor. This is the starting point the study compared everyone against.
rs117038461 is a single position in the genome, in or near the STAG3 gene. Published research associates it with ticagrelor levels in individuals with acute coronary syndromes treated with ticagrelor. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs117038461 linked to?
On MyGeneLog this position is linked to Coronary Artery Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs117038461 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs117038461 come from?
GWAS Catalog, European heart journal 2015, PMID:25935875. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Ticagrelor levels in individuals with acute coronary syndromes treated with ticagrelor (rs117038461). MyGeneLog™. https://www.mygenelog.com/variants/rs117038461