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Who was studied 6,536 British ancestry cases, 388,508 British ancestry controls.
The effect
Each copy of the A allele carried 1.16 times the odds of Kidney stones (95% confidence interval 1.11-1.22); p = 5 × 10−11.
How common The A allele had a frequency of about 18% in the people studied.
Where it sits Chromosome 13, band 13q14.11 — in an intron of DGKH.
What each result means
A/ATwo copies of the version the research linked to Kidney stones. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Kidney stones. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Kidney stones. This is the starting point the study compared everyone against.
Nature communications · 2019 · PMID 31729369 · open access
Questions about rs1170174
What is rs1170174?
rs1170174 is a single position in the genome, in or near the DGKH gene. Published research associates it with kidney stones. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1170174 linked to?
On MyGeneLog this position is linked to Kidney Stones. The research behind each link, and its sources, are set out on that condition page.
Does having rs1170174 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1170174 come from?
GWAS Catalog, Nature communications 2019, PMID:31729369. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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