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Thyroid cancer

MBIP · rs116909374

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

3 / 4

Its strongest genetic-study result is p = 10−256, with 28 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 27,758 European ancestry individuals; replicated in 1,156 European ancestry cases, up to 42,617 European ancestry controls.

The effect Each copy of the T allele carried 2.09 times the odds of Thyroid cancer (95% confidence interval 1.68-2.60); p = 5 × 10−11.

How common The T allele had a frequency of about 2% in the people studied.

Where it sits Chromosome 14, band 14q13.3 — in a non-coding transcript of LOC124903302.

How common each version is

CT
Japanese ToMMo
C 100.0% · T 0.0%
World gnomAD
C 97.7% · T 2.3%
World 1000 Genomes
C 98.9% · T 1.1%
World TOPMed
C 97.7% · T 2.3%

By ancestry gnomAD

European (non-Finnish)
C 96.5% · T 3.5%
African / African American
C 99.3% · T 0.7%
South Asian
C 99.5%
Admixed American (Latino)
C 98.2% · T 1.8%
Middle Eastern
C 95.2% · T 4.8%
Finnish
C 97.1% · T 2.9%
Ashkenazi Jewish
C 97.6% · T 2.4%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study. The ancestry rows are gnomAD's own groups (via Ensembl), as the survey defines them, not races. No Korean figure for this position yet.

What each result means

C/C No copy of the version the research linked to Thyroid cancer. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Thyroid cancer. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Thyroid cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Discovery of common variants associated with low TSH levels and thyroid cancer risk
Gudmundsson J, Sulem P, Gudbjartsson DF, Jonasson JG, Masson G, He H, Jonasdottir A, Sigurdsson A, Stacey SN, Johannsdottir H, Helgadottir HT, Li W
and 35 more — show all
Nagy R, Ringel MD, Kloos RT, de Visser MC, Plantinga TS, den Heijer M, Aguillo E, Panadero A, Prats E, Garcia-Castaño A, De Juan A, Rivera F, Walters GB, Bjarnason H, Tryggvadottir L, Eyjolfsson GI, Bjornsdottir US, Holm H, Olafsson I, Kristjansson K, Kristvinsson H, Magnusson OT, Thorleifsson G, Gulcher JR, Kong A, Kiemeney LA, Jonsson T, Hjartarson H, Mayordomo JI, Netea-Maier RT, de la Chapelle A, Hrafnkelsson J, Thorsteinsdottir U, Rafnar T, Stefansson K
Nature genetics · 2012 · PMID 22267200

In the news

2026-07-10 · Jee YH, et al. Nature Communications 2026, PMID:42431967

Genetic drivers of etiologic heterogeneity in thyroid cancer

Newly curated by the GWAS Catalog: 66 associations across 1 trait ("Thyroid cancer"), from Jee YH, et al. in Nature Communications, 2026. The catalogue records its sample as 10,717 cases and 1,262,106 controls. This site already has 22 of its 66 positions — 13 on the Thyroid Cancer page; 2 on the Ovarian Cancer page; 2 on the Blood Cell Counts page — including rs4733129 (NRG1), rs116909374 (MBIP), rs10069690 (TERT). Everything above is from the catalogue's records, assembled by code; the paper itself is linked. PMID:42431967.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Thyroid cancer (rs116909374). MyGeneLog™. https://www.mygenelog.com/variants/rs116909374

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