Gene Knowledge Graph
UTC
Standard

Central corneal thickness

NT5DC3 · rs116878472

Where this position leads

Condition: Central Corneal Thickness

rs116878472 Condition: Central Corneal Thickness Central Corneal Thickness Condition rs116878472 rs116878472 NT5DC3

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Central corneal thickness — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Central corneal thickness.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Central corneal thickness compared to the general population.
Source
Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases
Iglesias AI, Mishra A, Vitart V, Bykhovskaya Y, Höhn R, Springelkamp H, Cuellar-Partida G, Gharahkhani P, Bailey JNC, Willoughby CE, Li X, Yazar S
and 47 more — show all
Nag A, Khawaja AP, Polašek O, Siscovick D, Mitchell P, Tham YC, Haines JL, Kearns LS, Hayward C, Shi Y, van Leeuwen EM, Taylor KD, Bonnemaijer P, Rotter JI, Martin NG, Zeller T, Mills RA, Souzeau E, Staffieri SE, Jonas JB, Schmidtmann I, Boutin T, Kang JH, Lucas SEM, Wong TY, Beutel ME, Wilson JF, Uitterlinden AG, Vithana EN, Foster PJ, Hysi PG, Hewitt AW, Khor CC, Pasquale LR, Montgomery GW, Klaver CCW, Aung T, Pfeiffer N, Mackey DA, Hammond CJ, Cheng CY, Craig JE, Rabinowitz YS, Wiggs JL, Burdon KP, van Duijn CM, MacGregor S
Blue Mountains Eye Study—GWAS group · NEIGHBORHOOD Consortium · Wellcome Trust Case Control Consortium 2 (WTCCC2)
Nature communications · 2018 · PMID 29760442 · open access

Questions about rs116878472

What is rs116878472?

rs116878472 is a single position in the genome, in or near the NT5DC3 gene. Published research associates it with central corneal thickness. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs116878472 linked to?

On MyGeneLog this position is linked to Central Corneal Thickness. The research behind each link, and its sources, are set out on that condition page.

Does having rs116878472 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs116878472 come from?

GWAS Catalog, Nat Commun 2018, PMID:29760442. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

← See all variants