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Its strongest genetic-study result is p = 10−7, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 19,865 European ancestry cases, 623,043 European ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.091 higher (95% confidence interval 0.058-0.124); p = 4 × 10−8.
Where it sits Chromosome 7, band 7p12.2 — between genes, 14.7 kb from IKZF1.
What each result means
A/ATwo copies of the version the research linked to Multiple sclerosis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Multiple sclerosis. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Multiple sclerosis. This is the starting point the study compared everyone against.
rs116877451 is a single position in the genome, in or near the near IKZF1 gene. Published research associates it with multiple sclerosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs116877451 linked to?
On MyGeneLog this position is linked to Multiple Sclerosis. The research behind each link, and its sources, are set out on that condition page.
Does having rs116877451 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs116877451 come from?
GWAS Catalog, Nature genetics 2026, PMID:42706309. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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